Colorectal cancer (CRC) is the second leading cause of cancer-related death in the world. The majority of CRCs progress through the adenoma-carcinoma sequence, presenting opportunities to remove precursor lesions and prevent cancer or to identify CRC in its earliest, curable stages. There are also several modifiable dietary, lifestyle, and environmental risk factors for CRC. When detected in the preclinical stages, CRC tends to be localized and often curable with surgical resection with an excellent prognosis.
CRC screening efforts are directed towards the detection of early stage colorectal cancer and removal of pre-neoplastic lesions. There are several screening modalities that are effective and cost-effective, such as fecal immunochemical test, flexible sigmoidoscopy, CT colonography, and colonoscopy. In the last decade, studies have highlighted a worrisome increase in CRC incidence among younger individuals. In addition, the COVID-19 pandemic disrupted CRC screening programs and created a backlog of endoscopy procedures across the world. Continue reading here!
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